Genotyping of COVID-19 patient DNA
Worldwide there are ongoing efforts by the genetics community to help understand host genetics in relation to the SARS-CoV2 virus, and COVID-19. As one of our customers you can play an important role in this effort by genotyping your samples and contributing your data to a large analysis.
To facilitate this, Illumina and Thermofisher Scientific have kindly offered a discounted price for the Global Screening Array or Axiom Precision Medicine Array. Erasmus MC, and HuGe-F in particular, also feel the responsibility to help scientific progress in this field. We therefore offer free of charge genotyping of proven COVID-19 cases and discounted genotyping of COVID-19 related cases. The data of those samples will be returned to you for use in your own and in large-scale-scientific research.
COVID-19 host genetics initiative
We wish to point you to the COVID-19 host genetics initiative www.covid19hg.org, led by Mark Daly and Andrea Ganna from the Finnish Institute for Molecular Medicine (FIMM). This initiative aims to bring together the human genetics community to generate, share and analyze data to learn the genetic determinants of COVID-19 susceptibility, severity and outcomes.
We very much support this effort and hope that your genotype data can help this effort to produce useful results. Please join the COVID-19 host genetics initiative with your data on COVID-19 cases.
To ensure the provided genotype data is of use in the initiative, we have established a functional definition of a ‘proven COVID-19 cases’ and formulated criteria for free genotyping.
The criteria are as follows:
-- Samples of hospitalized patients with a positive SARS-CoV2 test
-- Informed consent from participating patients
-- Participating in the COVID-19 Host Genetics Initiative: www.covid19hg.org
-- Available phenotype data on at least age, sex, BMI, and co-morbidity such as diabetes, asthma, COPD, cardiovascular diseases. An extended dictionary for the use of variables in the covid19hg initiative will be prepared and shared.
-- DNA from blood, sputum, or nasal swabs (which have been used for virus detection) will be delivered to us following our shipment protocol
-- Signed contract for genotyping services
Please note that we have a limited amount of arrays that we can make available for free genotyping. We will therefore treat the requests for free genotyping on a ‘first come first serve’ basis, following the above-mentioned inclusion criteria.
Genotyping DNA from nasal swabs
HuGe-F has optimized the array protocol to be able to work with DNA from nasal swabs (as used in RT-PCR virus testing), so that this can be genotyped with an array resulting in good quality genotypes. Please contact us for more information.
Genotyping with attractive discount
We also offer genotyping with a discount up to 40%, of COVID-19 related cases, such as non-hospitalized patients with a positive SARS-CoV2 test, or control samples for proven COVID-19 case control analysis, or measurement of COVID-19 in existing cohorts/biobanks.
If you are interested, please contact Gaby van Dijk as soon as possible. Since most of us are working from home, please only use e-mail at this point to contact us.